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Semaglutide is a GLP-1 receptor agonist, a lab-made copy of a natural gut hormone your body releases after eating. In plain terms: it flips on your 'I'm full' signal, so you feel satisfied sooner, eat less, and your blood sugar steadies. It is the active drug in Ozempic and Wegovy.
Build & hold muscleBPC-157 is a synthetic chain of 15 amino acids based on a protective protein found in stomach acid. In plain terms: it seems to speed the body's own repair signals, especially for blood vessels and connective tissue, which is why people use it after injuries, though almost all evidence is from animals.
Weight lossRetatrutide is a triple agonist that switches on three hormone receptors at once: GLP-1, GIP, and glucagon. In plain terms: it copies three of your natural 'I'm full' and fat-burning signals together, which is why it drives some of the largest weight-loss numbers seen in trials. It is still experimental.
Recovery & muscleCJC-1295 without DAC (also called Mod GRF 1-29) is the short-acting version of the same GHRH analog. In plain terms: it gives a quick pulse of growth hormone closer to your body's natural rhythm, then clears fast, so it is usually paired with ipamorelin.
Recovery & muscleIpamorelin is a growth hormone secretagogue, specifically a ghrelin-receptor agonist (a GHRP). In plain terms: instead of injecting growth hormone, it signals your pituitary to release a clean pulse of your own, without much effect on hunger or stress hormones.
Skin & repairGHK-Cu is a natural copper-binding tripeptide (glycyl-histidyl-lysine plus copper) the body uses in tissue repair, and levels fall with age. In plain terms: applied to skin it signals collagen and healing, which is why it is a popular anti-aging skincare ingredient.
Commonly confused peptides
Long-form breakdowns of the pairs people confuse most, traced to primary sources.
Distributing HGH for anti-aging is a federal felony carrying five years. Sermorelin lost to it commercially in 2008 and can still be legally compounded.
Read comparisonMuscleNeither has a single published human trial, and sources give LR3's half-life as anywhere from 6 to 30 hours. There is an FDA approved IGF-1, and it is neither of these.
Read comparisonHealing and recoveryOne is approved in 35 countries and its largest trial found nothing. The other has never been injected in a published study.
Read comparisonMetabolic and weight lossBoth were tested in the same trial, in the same people, over the same 68 weeks. Semaglutide won on weight, and the combination beat both while coming in below their sum.
Read comparisonMetabolic and weight lossTirzepatide won the head-to-head at 20.2 percent against 13.7. The 47 percent figure everyone quotes is relative; the absolute gap is 6.5 points, from an open-label trial.
Read comparisonMetabolic and weight lossRetatrutide's 28.3 percent is being set against tirzepatide's 22.5 percent. Different trials, different lengths, and one of the numbers comes from a press release.
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